A new Developmental Cell paper by CMB graduate student Kasey Day overturns a longstanding view that the endocytic pathway in yeast mirrors that in mammalian cells. The authors systematically characterized the dynamics of the budding yeast endocytic pathway by tracking the movement of an internalized dye. This study from the
New technology developed in the Ruthenburg lab exposes widely held assumptions about antibody specificity and the practices of Chromatin Immunoprecipitation (ChIP) to be highly flawed. A recent Molecular Cell study led by undergraduate Rohan Shah and CMB graduate student Adrian Grzybowski, discovered that conventional methods for “validating antibodies” for use in ChIP display poor specificity.
Pulsed contractility is a dynamic form of actomyosin contractility that underlies many different kinds of morphogenetic processes. In a new paper published in the Journal of Cell Biology, CMB graduate student John Michaux and colleagues in the Munro Lab combine multicolor live imaging, single molecule analysis, genetic manipulations and mathematical modeling to identify a core biochemical circuit for pulsed contractility in early C. elegans embryos.
Current Whitehead fellow David Pincus, will be joining the Department of Molecular Genetics and Cell Biology with a joint appointment in the Center for Physics of Evolving Systems, starting in January. His lab studies how cells sense stress using the budding yeast model organism. The Pincus lab will focus on protein misfolding, proteostasis and stress response signaling pathways using a multidisciplinary combination of systematic genetics (both classical and chemical), computational modeling, protein biochemistry and genomics.