Student Publications

CMB students produce substantial bodies of work that lead to high quality, peer-reviewed publications. The menus below highlight papers our students have published in recent years.

Accordion: 
2018

Spatiotemporal Regulation of RhoA during Cytokinesis.
Angika Basant, Glotzer M.
Curr Biol. 2018 May 7;28(9):R570-R580. doi: 10.1016/j.cub.2018.03.045.

Underground azelaic acid-conferred resistance to Pseudomonas syringae in Arabidopsis.
Cecchini NM, Roychoudhry S, Dequantarius J Speed, Steffes K, Tambe A, Zodrow K, Konstantinoff K, Jung HW, Engle N, Tschaplinski TJ, Greenberg J.
Mol Plant Microbe Interact. 2018 Aug 29. doi: 10.1094/MPMI-07-18-0185-R.

Budding Yeast Has a Minimal Endomembrane System.
Kasey J Day, Jason C Casler, Glick BS.
Dev Cell. 2018 Jan 8;44(1):56-72.e4. doi: 10.1016/j.devcel.2017.12.014.

Facile target validation in an animal model with intracellularly expressed monobodies.
Gupta A, Xu J, Lee S, Tsai ST, Zhou B, Kurosawa K, Michael S Werner, Koide A, Ruthenburg AJ, Dou Y, Koide S.
Nat Chem Biol. 2018 Sep;14(9):895-900. doi: 10.1038/s41589-018-0099-z. Epub 2018 Jul 16.

Regulated Capture of Vκ Gene Topologically Associating Domains by Transcription Factories.
Karki S, Kennedy DE, Mclean K, Adrian T Grzybowski, Maienschein-Cline M, Banerjee S, Xu H, Davis E, Mandal M, Labno C, Powers SE, Le Beau MM, Dinner AR, Singh H, Ruthenburg AJ, Clark MR.
Cell Rep. 2018 Aug 28;24(9):2443-2456. doi: 10.1016/j.celrep.2018.07.091.

Targeting the MTF2-MDM2 Axis Sensitizes Refractory Acute Myeloid Leukemia to Chemotherapy.
Maganti HB, Jrade H, Cafariello C, Manias Rothberg JL, Porter CJ, Yockell-Lelièvre J, Battaion HL, Khan ST, Howard JP, Li Y, Adrian T Grzybowski, Sabri E, Ruthenburg AJ, Dilworth FJ, Perkins TJ, Sabloff M, Ito CY, Stanford WL.
Cancer Discov. 2018 Aug 16. doi: 10.1158/2159-8290.CD-17-0841.        

Excitable RhoA dynamics drive pulsed contractions in the early C. elegans embryo.
Jonathan B Michaux, Robin FB, McFadden WM, Munro EM.
J Cell Biol. 2018 Oct 1. pii: jcb.201806161. doi: 10.1083/jcb.201806161.

Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies.
Shah RN, Adrian T Grzybowski, Cornett EM, Johnstone AL, Dickson BM, Boone BA, Cheek MA, Cowles MW, Maryanski D, Meiners MJ, Tiedemann RL, Vaughan RM, Arora N, Sun ZW, Rothbart SB, Keogh MC, Ruthenburg AJ.
Mol Cell. 2018 Oct 4;72(1):162-177.e7. doi: 10.1016/j.molcel.2018.08.015. Epub 2018 Sep 20.

Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm.
Yang XH, Nadadur RD, Hilvering CR, Bianchi V, Michael Werner, Mazurek SR, Gadek M, Shen KM, Goldman JA, Tyan L, Bekeny J, Hall JM, Lee N, Perez-Cervantes C, Burnicka-Turek O, Poss KD, Weber CR, de Laat W, Ruthenburg AJ, Moskowitz IP.
Elife. 2017 Dec 27;6. pii: e31683. doi: 10.7554/eLife.31683.

2017

A GAP that Divides.
Angika Basant, Glotzer M.
F1000Res. 2017 Oct 2;6:1788. doi: 10.12688/f1000research.12064.1. eCollection 2017.
Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres.

The bacterial virulence factors VopL and VopF nucleate actin from the pointed end.
Thomas A Burke, Harker AJ, Dominguez R, Kovar DR.
J Cell Biol. 2017 May 1;216(5):1267-1276. doi: 10.1083/jcb.201608104. Epub 2017 Mar 31.

Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks.
Jenna R Christensen, Hocky GM, Kaitlin E Homa, Morganthaler AN, Hitchcock-DeGregori SE, Voth GA, Kovar DR.
Elife. 2017 Mar 10;6. pii: e23152. doi: 10.7554/eLife.23152.

Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres.
Oakes PW, Elizabeth Wagner, Brand CA, Probst D, Linke M, Schwarz US, Glotzer M, Gardel ML.
Nat Commun. 2017 Jun 12;8:15817. doi: 10.1038/ncomms15817.

Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription.Michael S Werner, Sullivan MA, Shah RN, Nadadur RD, Adrian T Grzybowski, Galat V, Moskowitz IP, Ruthenburg AJ.
Nat Struct Mol Biol. 2017 Jul;24(7):596-603. doi: 10.1038/nsmb.3424. Epub 2017 Jun 19.

Cell cycle entry triggers a switch between two modes of Cdc42 activation during yeast polarization.
Kristen Witte, Strickland D, Glotzer M.
Elife. 2017 Jul 6;6. pii: e26722. doi: 10.7554/eLife.26722.

A Suite of Receptor-Like Kinases and a Putative Mechano-Sensitive Channel Are Involved in Autoimmunity and Plasma Membrane-Based Defenses in Arabidopsis.
Zhang Z, Tateda C, Jiang SC, Shrestha J, Jelenska J, Dequantarius J Speed, Greenberg JT.
Mol Plant Microbe Interact. 2017 Feb;30(2):150-160. doi: 10.1094/MPMI-09-16-0184-R. Epub 2017 Mar 3.

Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly.
Zimmermann D, Kaitlin E Homa, Hocky GM, Pollard LW, De La Cruz EM, Voth GA, Trybus KM, Kovar DR.
Nat Commun. 2017 Sep 26;8(1):703. doi: 10.1038/s41467-017-00445-3.

2016

Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation.
Hattori T, Lai D, Dementieva IS, Montaño SP, Kurosawa K, Zheng Y, Akin LR, Świst-Rosowska KM, Adrian T Grzybowski, Koide A, Krajewski K, Strahl BD, Kelleher NL, Ruthenburg AJ, Koide S.
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2092-7. doi: 10.1073/pnas.1522691113. Epub 2016 Feb 9.

The F-actin bundler α-actinin Ain1 is tailored for ring assembly and constriction during cytokinesis in fission yeast.
Li Y, Jenna R Christensen, Kaitlin E Homa, Hocky GM, Fok A, Sees JA, Voth GA, Kovar DR.
Mol Biol Cell. 2016 Jun 1;27(11):1821-33. doi: 10.1091/mbc.E16-01-0010. Epub 2016 Apr 13.

Spliceosomal DEAH-Box ATPases Remodel Pre-mRNA to Activate Alternative Splice Sites.
Daniel R Semlow, Blanco MR, Walter NG, Staley JP.
Cell. 2016 Feb 25;164(5):985-98. doi: 10.1016/j.cell.2016.01.025.

Local RhoA activation induces cytokinetic furrows independent of spindle position and cell cycle stage.
Elizabeth Wagner, Glotzer M.
J Cell Biol. 2016 Jun 20;213(6):641-9. doi: 10.1083/jcb.201603025. Epub 2016 Jun 13.

Fascin- and α-Actinin-Bundled Networks Contain Intrinsic Structural Features that Drive Protein Sorting.
Jonathan D Winkelman, Suarez C, Hocky GM, Harker AJ, Morganthaler AN, Jenna R Christensen, Voth GA, Bartles JR, Kovar DR.
Curr Biol. 2016 Oct 24;26(20):2697-2706. doi: 10.1016/j.cub.2016.07.080. Epub 2016 Sep 22.

2015

Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane.
Angika Basant, Lekomtsev S, Tse YC, Zhang D, Longhini KM, Petronczki M, Glotzer M.
Dev Cell. 2015 Apr 20;33(2):204-15. doi: 10.1016/j.devcel.2015.03.015.

Fission yeast profilin is tailored to facilitate actin assembly by the cytokinesis formin Cdc12.
Andrew J Bestul, Jenna R Christensen, Grzegorzewska AP, Thomas A Burke, Sees JA, Carroll RT, Sirotkin V, Keenan RJ, Kovar DR.
Mol Biol Cell. 2015 Jan 15;26(2):283-93. doi: 10.1091/mbc.E13-05-0281. Epub 2014 Nov 12.

Calibrating ChIP-Seq with Nucleosomal Internal Standards to Measure Histone Modification Density Genome Wide.
Adrian T Grzybowski, Chen Z, Ruthenburg AJ.
Mol Cell. 2015 Jun 4;58(5):886-99. doi: 10.1016/j.molcel.2015.04.022. Epub 2015 May 21.

ACTIN-DIRECTED TOXIN. ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.
Heisler DB, Kudryashova E, Grinevich DO, Suarez C, Jonathan D Winkelman, Birukov KG, Kotha SR, Parinandi NL, Vavylonis D, Kovar DR, Kudryashov DS.
Science. 2015 Jul 31;349(6247):535-9. doi: 10.1126/science.aab4090.

An Interactive Database for the Assessment of Histone Antibody Specificity.
Rothbart SB, Dickson BM, Raab JR, Adrian T Grzybowski, Krajewski K, Guo AH, Shanle EK, Josefowicz SZ, Fuchs SM, Allis CD, Magnuson TR, Ruthenburg AJ, Strahl BD.
Mol Cell. 2015 Aug 6;59(3):502-11. doi: 10.1016/j.molcel.2015.06.022. Epub 2015 Jul 23.

Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.
Rotty JD, Wu C, Haynes EM, Suarez C, Jonathan D Winkelman, Johnson HE, Haugh JM, Kovar DR, Bear JE.
Dev Cell. 2015 Jan 12;32(1):54-67. doi: 10.1016/j.devcel.2014.10.026. Epub 2014 Dec 24.

Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex.
Suarez C, Carroll RT, Thomas A Burke, Jenna R Christensen, Andrew J Bestul, Sees JA, James ML, Sirotkin V, Kovar DR.
Dev Cell. 2015 Jan 12;32(1):43-53. doi: 10.1016/j.devcel.2014.10.027. Epub 2014 Dec 24.

Nuclear Fractionation Reveals Thousands of Chromatin-Tethered Noncoding RNAs Adjacent to Active Genes.
Michael S Werner, Ruthenburg AJ.
Cell Rep. 2015 Aug 18;12(7):1089-98. doi: 10.1016/j.celrep.2015.07.033. Epub 2015 Aug 6.

2014

Enabled negatively regulates diaphanous-driven actin dynamics in vitro and in vivo.
Bilancia CG, Jonathan D Winkelman, Tsygankov D, Nowotarski SH, Sees JA, Comber K, Evans I, Lakhani V, Wood W, Elston TC, Kovar DR, Peifer M

Homeostatic actin cytoskeleton networks are regulated by assembly factor competition for monomers.
Thomas A Burke, Jenna R Christensen, Barone E, Suarez C, Sirotkin V, Kovar DR.
Curr Biol. 2014 Mar 3;24(5):579-85. doi: 10.1016/j.cub.2014.01.072. Epub 2014 Feb 20.

Traceless semisynthesis of a set of histone 3 species bearing specific lysine methylation marks.
Chen Z, Adrian T Grzybowski, Ruthenburg AJ.
Chembiochem. 2014 Sep 22;15(14):2071-5. doi: 10.1002/cbic.201402313. Epub 2014 Aug 22.

Rhythms in energy storage control the ability of the cyanobacterial circadian clock to reset.
Pattanayak GK, Connie Phong, Rust MJ.
Curr Biol. 2014 Aug 18;24(16):1934-8. doi: 10.1016/j.cub.2014.07.022. Epub 2014 Aug 7.

Ena/VASP Enabled is a highly processive actin polymerase tailored to self-assemble parallel-bundled F-actin networks with Fascin.
Jonathan D Winkelman, Bilancia CG, Peifer M, Kovar DR.
Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4121-6. doi: 10.1073/pnas.1322093111. Epub 2014 Mar 3.