Trans-Golgi Express

By Alex Ruthenburg

A new Developmental Cell paper by CMB graduate student Kasey Day overturns a longstanding view that the endocytic pathway in yeast mirrors that in mammalian cells. The authors systematically characterized the dynamics of the budding yeast endocytic pathway by tracking the movement of an internalized dye. This study from the Glick lab reveals a streamlined trafficking system in yeast, which lacks distinct early and recycling endosomes, and instead uses the trans-Golgi network to perform both of these roles.