Jocelyn Malamy

Associate Professor
Research Summary
My lab works in two model systems: the model plant Arabidopsis thaliana and the emerging model Cnidarian Clytia hemisphaerica. In Arabidopsis, we are studying long distance signaling via the phloem. While it is known that a complex and dynamic array of signals move through the phloem, the identity and function of these signals is still largely unknown. In unpublished work we have developed a novel system for isolating phloem sap for analysis of protein signaling molecules. Our goal is to determine mechanism for modulation of phloem signaling molecules in response to environmental cues. In Clytia, we have recently started a new project to understand wound healing and regeneration. Regenerative capabilities in Cnidarians are second only to plants. We have found that epithelial healing is at least 100x faster in Cnidarians that in other model systems, and can be visualized at high resolution in this transparent marine animal. Current work focuses on characterizing wound healing processes and developing tools for genome editing.
Arabidopsis thaliana, jellyfish, regeneration, wound healing, Phloem
  • Tufts University, Medford, MA, BS Biology 07/1985
  • Rutgers, The State University of New Jersey, New Brunswick, NY, Ph.D. Microbiology 09/1993
  • New York University, New York, NY, Post Doctoral Fellowship Plant Biology 1999
  1. Malamy JE, Shribak M. An orientation-independent DIC microscope allows high resolution imaging of epithelial cell migration and wound healing in a cnidarian model. J Microsc. 2018 06; 270(3):290-301. View in: PubMed

  2. Kamran Z, Zellner K, Kyriazes H, Kraus CM, Reynier JB, Malamy JE. In vivo imaging of epithelial wound healing in the cnidarian Clytia hemisphaerica demonstrates early evolution of purse string and cell crawling closure mechanisms. BMC Dev Biol. 2017 12 19; 17(1):17. View in: PubMed

  3. Roycewicz PS, Malamy JE. Cell wall properties play an important role in the emergence of lateral root primordia from the parent root. J Exp Bot. 2014 May; 65(8):2057-69. View in: PubMed

  4. Roycewicz P, Malamy JE. Dissecting the effects of nitrate, sucrose and osmotic potential on Arabidopsis root and shoot system growth in laboratory assays. Philos Trans R Soc Lond B Biol Sci. 2012 Jun 05; 367(1595):1489-500. View in: PubMed

  5. Ingram P, Dettmer J, Helariutta Y, Malamy JE. Arabidopsis Lateral Root Development 3 is essential for early phloem development and function, and hence for normal root system development. Plant J. 2011 Nov; 68(3):455-67. View in: PubMed

  6. Malamy J. Transgene expression in regenerated roots. CSH Protoc. 2007 Feb 01; 2007:pdb.prot4691. View in: PubMed

  7. Macgregor DR, Deak KI, Ingram PA, Malamy JE. Root system architecture in Arabidopsis grown in culture is regulated by sucrose uptake in the aerial tissues. Plant Cell. 2008 Oct; 20(10):2643-60. View in: PubMed

  8. Malamy J, Carr JP, Klessig DF, Raskin I. Salicylic Acid: a likely endogenous signal in the resistance response of tobacco to viral infection. Science. 1990 Nov 16; 250(4983):1002-4. View in: PubMed

  9. Little DY, Rao H, Oliva S, Daniel-Vedele F, Krapp A, Malamy JE. The putative high-affinity nitrate transporter NRT2.1 represses lateral root initiation in response to nutritional cues. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13693-8. View in: PubMed

  10. Fitz Gerald JN, Lehti-Shiu MD, Ingram PA, Deak KI, Biesiada T, Malamy JE. Identification of quantitative trait loci that regulate Arabidopsis root system size and plasticity. Genetics. 2006 Jan; 172(1):485-98. View in: PubMed

  11. Malamy JE. Intrinsic and environmental response pathways that regulate root system architecture. Plant Cell Environ. 2005 Jan; 28(1):67-77. View in: PubMed

  12. Deak KI, Malamy J. Osmotic regulation of root system architecture. Plant J. 2005 Jul; 43(1):17-28. View in: PubMed

  13. Nawy T, Lee JY, Colinas J, Wang JY, Thongrod SC, Malamy JE, Birnbaum K, Benfey PN. Transcriptional profile of the Arabidopsis root quiescent center. Plant Cell. 2005 Jul; 17(7):1908-25. View in: PubMed

  14. Malamy J, Hennig J, Klessig DF. Temperature-Dependent Induction of Salicylic Acid and Its Conjugates during the Resistance Response to Tobacco Mosaic Virus Infection. Plant Cell. 1992 Mar; 4(3):359-366. View in: PubMed

  15. Malamy JE, Ryan KS. Environmental regulation of lateral root initiation in Arabidopsis. Plant Physiol. 2001 Nov; 127(3):899-909. View in: PubMed

  16. Chen Z, Malamy J, Henning J, Conrath U, Sánchez-Casas P, Silva H, Ricigliano J, Klessig DK. Induction, modification, and transduction of the salicylic acid signal in plant defense responses. Proc Natl Acad Sci U S A. 1995 May 09; 92(10):4134-7. View in: PubMed

  17. Wysocka-Diller JW, Helariutta Y, Fukaki H, Malamy JE, Benfey PN. Molecular analysis of SCARECROW function reveals a radial patterning mechanism common to root and shoot. Development. 2000 Feb; 127(3):595-603. View in: PubMed

  18. Sabatini S, Beis D, Wolkenfelt H, Murfett J, Guilfoyle T, Malamy J, Benfey P, Leyser O, Bechtold N, Weisbeek P, Scheres B. An auxin-dependent distal organizer of pattern and polarity in the Arabidopsis root. Cell. 1999 Nov 24; 99(5):463-72. View in: PubMed

  19. Malamy JE, Benfey PN. Analysis of SCARECROW expression using a rapid system for assessing transgene expression in Arabidopsis roots. Plant J. 1997 Oct; 12(4):957-63. View in: PubMed

  20. Malamy JE, Benfey PN. Organization and cell differentiation in lateral roots of Arabidopsis thaliana. Development. 1997 Jan; 124(1):33-44. View in: PubMed

  21. Di Laurenzio L, Wysocka-Diller J, Malamy JE, Pysh L, Helariutta Y, Freshour G, Hahn MG, Feldmann KA, Benfey PN. The SCARECROW gene regulates an asymmetric cell division that is essential for generating the radial organization of the Arabidopsis root. Cell. 1996 Aug 09; 86(3):423-33. View in: PubMed

  22. Hennig J, Malamy J, Grynkiewicz G, Indulski J, Klessig DF. Interconversion of the salicylic acid signal and its glucoside in tobacco. Plant J. 1993 Oct; 4(4):593-600. View in: PubMed

  23. Klessig DF, Malamy J. The salicylic acid signal in plants. Plant Mol Biol. 1994 Dec; 26(5):1439-58. View in: PubMed

  24. Klessig DF, Malamy J, Hennig J, Sanchez-Casas P, Indulski J, Grynkiewicz G, Chen Z. Induction, modification, and perception of the salicylic acid signal in plant defence. Biochem Soc Symp. 1994; 60:219-29. View in: PubMed